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Table 3: Search for SR and MA Search Benefit and harms of mammography screening (40-49 y) questions Note Specific search for systematic reviews and meta-analysis Date 19/04/2010 Keywords Breast neoplasms (MESH) and mass screening (or early detection) (MESH) and mammography (MESH) Medline 1 meta-analysis.pt,ti,ab,sh (34320) 27 (1 duplicate) (OVID): 2 1 or (meta anal$ or metaanal$).ti,ab,sh (43943) Filter 3 (methodol$ or systematic$ or quantitativ$).ti,ab,sh.
Table 1: Search for SR and MA Search Benefit and harms of mammography screening (40-49 y) questions Note Specific search for systematic reviews and meta-analysis Date 19/04/2010 Keywords Breast neoplasms (MESH) and mass screening (or early detection) (MESH) and mammography (MESH) Medline 1 meta-analysis.pt,ti,ab,sh (34320) 27 (1 duplicate) (OVID): 2 1 or (meta anal$ or metaanal$).ti,ab,sh (43943) Filter 3 (methodol$ or systematic$ or quantitativ$).ti,ab,sh.

Table 4: Search for additional RCTs Search Benefit and harms of mammography screening (40-49 y) questions Note Specific search for RCT’s Date 27/04/2010 Keywords Breast neoplasms (MESH), mass screening (or early detection) (MESH), mammography (MESH) Medline 1 Randomized controlled trials/ (66083) Medline (OVID): (OVID): 2 Randomized controlled trial.pt (289038) Filter Filter 3 Random allocation/ (67885) RCT RCT 4 Double blind method/ (105956) 5 Single blind method/ (13834) 6 Clinical trial.pt (460563) 7 exp clinical trial/ (606505) 8 or/1-7 (718664) 9 (clinic$ adj trial$).tw (146686) 10 ((singl$ or doubl$ or treb$ or tripl$) adj (blind$3 or mask$3)).tw (105209) 11 Placebos/ (28712) 12 Placebo$.tw (125428) 13 Randomly allocated.tw (12231) 14 (allocated adj2 random).tw (654) 15 9 or 10 or 11 or 12 or 13 or 14 (312732) 16 8 or 15 (842155) 17 Case report.tw (155883) 18 Letter.pt (688664) 19 Historical article.pt (263287) 20 Review of reported cases.pt (0) 21 Review,multicase.pt (0) 22 17 or 18 or 19 or 20 or 21 (1098644) 23 16 not 22 (822810) 24 Breast/ or Breast Diseases/ (30717) 25 Neoplasms/ (216644) 26 24 and 25 (535) 27 (breast$ adj5 neoplasm$).tw (1588) 28 (breast$ adj5 cancer$).tw (135654) 29 (breast$ adj5 carcin$).tw (31778) 30 (breast$ adj5 tumo$).tw (23438) 31 (breast$ adj5 metasta$).tw (16580) 32 (breast$ adj5 malig$).tw (7361) 33 exp Breast Neoplasms/ (171606) 34 exp Carcinoma, Ductal, Breast/ (8460) 35 26 or 27 or 28 or 29 or 30 or 31 or 32 or 33 or 34 (207174) 36 mammography.mp (23598) 37 screening.mp (274211) 38 36 or 37 (288429) 39 23 and 35 and 38 (2326) 40 limit 39 to (yr=" 2008 -Current" and " all adult (19 plus years)" and (dutch or english or french)) (241) 41 from 40 keep 1-241 (241) 42 from 41 keep 1-241 (241) CENTRAL Breast neoplasms (MESH) and early detection (MESH) or 61 mammography (MESH) (manual limit 2008-2010) in title , abstracts or key words
Table 2: Search for additional RCTs Search Benefit and harms of mammography screening (40-49 y) questions Note Specific search for RCT’s Date 27/04/2010 Keywords Breast neoplasms (MESH), mass screening (or early detection) (MESH), mammography (MESH) Medline 1 Randomized controlled trials/ (66083) Medline (OVID): (OVID): 2 Randomized controlled trial.pt (289038) Filter Filter 3 Random allocation/ (67885) RCT RCT 4 Double blind method/ (105956) 5 Single blind method/ (13834) 6 Clinical trial.pt (460563) 7 exp clinical trial/ (606505) 8 or/1-7 (718664) 9 (clinic$ adj trial$).tw (146686) 10 ((singl$ or doubl$ or treb$ or tripl$) adj (blind$3 or mask$3)).tw (105209) 11 Placebos/ (28712) 12 Placebo$.tw (125428) 13 Randomly allocated.tw (12231) 14 (allocated adj2 random).tw (654) 15 9 or 10 or 11 or 12 or 13 or 14 (312732) 16 8 or 15 (842155) 17 Case report.tw (155883) 18 Letter.pt (688664) 19 Historical article.pt (263287) 20 Review of reported cases.pt (0) 21 Review,multicase.pt (0) 22 17 or 18 or 19 or 20 or 21 (1098644) 23 16 not 22 (822810) 24 Breast/ or Breast Diseases/ (30717) 25 Neoplasms/ (216644) 26 24 and 25 (535) 27 (breast$ adj5 neoplasm$).tw (1588) 28 (breast$ adj5 cancer$).tw (135654) 29 (breast$ adj5 carcin$).tw (31778) 30 (breast$ adj5 tumo$).tw (23438) 31 (breast$ adj5 metasta$).tw (16580) 32 (breast$ adj5 malig$).tw (7361) 33 exp Breast Neoplasms/ (171606) 34 exp Carcinoma, Ductal, Breast/ (8460) 35 26 or 27 or 28 or 29 or 30 or 31 or 32 or 33 or 34 (207174) 36 mammography.mp (23598) 37 screening.mp (274211) 38 36 or 37 (288429) 39 23 and 35 and 38 (2326) 40 limit 39 to (yr=" 2008 -Current" and " all adult (19 plus years)" and (dutch or english or french)) (241) 41 from 40 keep 1-241 (241) 42 from 41 keep 1-241 (241) CENTRAL Breast neoplasms (MESH) and early detection (MESH) or 61 mammography (MESH) (manual limit 2008-2010) in title , abstracts or key words

Search for Evidence & Critical Appraisal: Health Services Research (HSR)
Search for Evidence & Critical Appraisal: Health Services Research (HSR)

Search for Evidence & Critical Appraisal: Health technology Assessment (HTA)
Search for Evidence & Critical Appraisal: Health technology Assessment (HTA)

Götsche (USPTSF) 10 (Cochrane) 7 Interventie mammography screening Search : Dec 2008 Search : Nov 2008 ?
Götsche (USPTSF) 9 (Cochrane) 6 Interventie mammography screening Search : Dec 2008 Search : Nov 2008 ?

of Canada 53) et (4) PUBMED search.
Verloskundigen 50 , Nederlandse Vereniging voor Obstetrie en Gynecologie 51 , Wetenschappelijke Vereniging Huisartsen 52 , Society of Obstetricians and Gynecologists of Canada 53 ), en (4) PUBMED search.

Les documents peuvent être consultés librement sur le site Web de l’EMA: www.ema.europa.eu/ ema/index.jsp?curl=pages/medicines/landing/ herbal_search.jsp&murl=menus/medicines/ medicines. jsp&mid=WC0b01ac058001fa1d L’évaluation des plantes (ou herbal substances) qui entrent en ligne de compte comme médicaments (ou herbal medicinal products) se penche sur leur qualité, innocuité et efficacité.
De documenten zijn vrij raadpleegbaar op de website van de EMA: www.ema.europa.eu/ema/index. jsp?curl=pages/medicines/landing/herbal_ search.jsp&murl=menus/medicines/medicines. jsp&mid=WC0b01ac058001fa1d Bij de evaluatie van kruiden of herbal substances die in aanmerking komen als geneesmiddelen of herbal medicinal products spelen kwaliteit, veiligheid en doeltreffendheid een rol.

Table 5: Update of evidence found in SR and HTA Search Radiation harms of mammography screening (40-49 y) questions Note Update of HTA (ETMIS) Date 03/05/2010 Keywords Breast neoplasms, mammography/ adverse effects, mass screening/ adverse effects Medline Case report.tw (156081) (OVID): 2 Letter.pt (689184) Filter 3 Historical article.pt (263481) RCT 4 Review of reported cases.pt (0) 5 Review,multicase.pt (0) 6 or/1-5 (1099551) 7 Breast/ or Breast Diseases/ (30731) 8 Neoplasms/ (216844) 9 7 and 8 (536) 10 exp Breast Neoplasms/ (171800) 11 (breast$ adj5 neoplas$).tw (2557) 12 (breast$ adj5 cancer$).tw (135752) 13 (breast$ adj5 carcin$).tw (31777) 14 (breast$ adj5 tumo$).tw (23441) 15 (breast$ adj5 metasta$).tw (16582) 16 (breast$ adj5 malig$).tw (7361) 17 exp Carcinoma, Ductal, Breast/ (8472) 18 9 or 10 or 11 or 12 or 13 or 14 or 15 or 16 or 17 (207367) 19 Mammography/ae [Adverse Effects] (517) 20 Mass Screening/ae [Adverse Effects] (325) 21 19 or 20 (763) 22 18 and 21 (443) 23 22 not 6 (379) 24 limit 23 to (yr=" 2005 -Current" and " all adult (19 plus years)" and (dutch or english or french)) (44) 25 from 24 keep 1-44 (44)
Table 3: Update of evidence found in SR and HTA Search Radiation harms of mammography screening (40-49 y) questions Note Update of HTA (ETMIS) Date 03/05/2010 Keywords Breast neoplasms, mammography/ adverse effects, mass screening/ adverse effects Medline Case report.tw (156081) (OVID): 2 Letter.pt (689184) Filter 3 Historical article.pt (263481) RCT 4 Review of reported cases.pt (0) 5 Review,multicase.pt (0) 6 or/1-5 (1099551) 7 Breast/ or Breast Diseases/ (30731) 8 Neoplasms/ (216844) 9 7 and 8 (536) 10 exp Breast Neoplasms/ (171800) 11 (breast$ adj5 neoplas$).tw (2557) 12 (breast$ adj5 cancer$).tw (135752) 13 (breast$ adj5 carcin$).tw (31777) 14 (breast$ adj5 tumo$).tw (23441) 15 (breast$ adj5 metasta$).tw (16582) 16 (breast$ adj5 malig$).tw (7361) 17 exp Carcinoma, Ductal, Breast/ (8472) 18 9 or 10 or 11 or 12 or 13 or 14 or 15 or 16 or 17 (207367) 19 Mammography/ae [Adverse Effects] (517) 20 Mass Screening/ae [Adverse Effects] (325) 21 19 or 20 (763) 22 18 and 21 (443) 23 22 not 6 (379) 24 limit 23 to (yr=" 2005 -Current" and " all adult (19 plus years)" and (dutch or english or french)) (44) 25 from 24 keep 1-44 (44)

Les documents peuvent être consultés librement sur le site Web de l’EMA: www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/landing/herbal_search.jsp&murl=menus/medicines/medicines.jsp∣ =WC0b01ac058001fa1d
De documenten zijn vrij raadpleegbaar op de website van de EMA: www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/landing/herbal_search.jsp&murl=menus/medicines/medicines.jsp∣ =WC0b01ac058001fa1d

L’EMA a achevé son évaluation le 26 juillet 2013 et conclut qu’il n’existe pour le moment aucune preuve d’un lien causal entre les antidiabétiques concernés et une pancréatite ou un cancer du pancréas (via www.ema.europa.eu , cliquez " Document search" , mot-clé: " GLP-1 therapies" ).
Het EMA heeft op 26 juli 2013 haar analyse van het signaal afgerond, en besluit dat er voorlopig geen causaal verband tussen de betrokken antidiabetica en pancreatitis en pancreaskanker is aangetoond (via www.ema.europa.eu , klik " Document search" , zoekterm: " GLP-1 therapies" ).