Traduction de «side-effects of buproprion » (Français → Néerlandais) :

Odds ratio of NRT versus control: 1.67 Odds ratio of Buproprion versus control: 2.1 Odds ratio of NRT+Buproprion versus control: 2.65 From these Odds Ratios and information on the control 12-month quit rate in the comparator intervention (0.04 for brief advice and 0.10 for counselling), the 12-month quit rate of treatment is calculated: treated quit rate for brief advice+NRT: 0.0650 treated quit rate for brief advice+Buproprion: 0.0805 treated quit rate for brief advice+Buproprion+NRT: 0.0994 treated quit rate for counselling+NRT: 0.1565 treated quit rate for counselling+Buproprion: 0.1892 treated quit rate for counselling+Buproprion+NRT: 0.2275 spontaneous cessation rate: 0.01. lifetime relapse rate: 40% (range 30-50%). number of LYG per quitter: 2 (range 1-3). number of QALYs gained per quitter: 2.7 (range 1.35-4.05) not reported The table gives an overview of the assumptions with respect to costs and effects (quit rates) in the average scenario.
Odds ratio of NRT versus control: 1.67 Odds ratio of bupropion versus control: 2.1 Odds ratio of NRT+bupropion versus control: 2.65 From these Odds Ratios and information on the control 12-month quit rate in the comparator intervention (0.04 for brief advice and 0.10 for counselling), the 12-month quit rate of treatment is calculated: treated quit rate for brief advice+NRT: 0.0650 treated quit rate for brief advice+bupropion: 0.0805 treated quit rate for brief advice+bupropion+NRT: 0.0994 treated quit rate for counselling+NRT: 0.1565 treated quit rate for counselling+bupropion: 0.1892 treated quit rate for counselling+bupropion+NRT: 0.2275 spontaneous cessation rate: 0.01. lifetime relapse rate: 40% (range 30-50%). number of LYG per quitter: 2 (range 1-3). number of QALYs gained per quitter: 2.7 (range 1.35-4.05) not reported The table gives an overview of the assumptions with respect to costs and effects (quit rates) in the average scenario.

Costs and consequences of side-effects of Buproprion or NRT were not taken into account
Costs and consequences of side-effects of bupropion or NRT were not taken into account

patients remain on one type of treatment throughout their smoking cessation therapy costs and consequences of side-effects of Buproprion or NRT were not taken into account
patients remain on one type of treatment throughout their smoking cessation therapy costs and consequences of side-effects of bupropion or NRT were not taken into account

Spontaneous cessation rate: 2.5% OR counselling only: 1.73 Incremental OR NRT gum (relative to counselling only): 1.63 Incremental OR NRT patch (relative to counselling only): 1.79 Incremental OR NRT spray (relative to counselling only): 2.35 Incremental OR NRT inhaler (relative to counselling only): 2.14 Incremental OR Buproprion (relative to counselling only): 2.30 % of smokers still under treatment after the first month: 50% (range 40-60% in sensitivity analysis) % of smokers still under treatment after the second month: 20% (range 15-25% in sensitivity analysis) Lifetime relapse probability after one year of abstinence: 35% (range 10-50% in sensitivity analysis) Effect of smoking cessation on mortality derived from the results of the American Cancer Society Prevention Study II. The mortality rate for former smokers was projected by calculating a weighted average of the incremental differentials between mortality rates of neversmokers and smokers, weighted according to the duration of abstinence.
Spontaneous cessation rate: 2.5% OR counselling only: 1.73 Incremental OR NRT gum (relative to counselling only): 1.63 Incremental OR NRT patch (relative to counselling only): 1.79 Incremental OR NRT spray (relative to counselling only): 2.35 Incremental OR NRT inhaler (relative to counselling only): 2.14 Incremental OR bupropion (relative to counselling only): 2.30 % of smokers still under treatment after the first month: 50% (range 40-60% in sensitivity analysis) % of smokers still under treatment after the second month: 20% (range 15-25% in sensitivity analysis) Lifetime relapse probability after one year of abstinence: 35% (range 10-50% in sensitivity analysis) Effect of smoking cessation on mortality derived from the results of the American Cancer Society Prevention Study II. The mortality rate for former smokers was projected by calculating a weighted average of the incremental differentials between mortality rates of neversmokers and smokers, weighted according to the duration of abstinence.

Side effects of the patch
Side effects of the gum

D’après Meyler’s Side Effects of Drugs et Martindale, toutes les héparines, y compris les héparines de bas poids moléculaire, peuvent provoquer dans de rares cas une hyperkaliémie, surtout lorsque le traitement dépasse les 7 jours; celle-ci peut être cliniquement importante, a fortiori en présence d’autres facteurs de risque.
Volgens Meyler’s Side Effects of Drugs en Martindale kunnen alle heparines, met inbegrip van de heparines met laag moleculair gewicht, in zeldzame gevallen hyperkaliëmie veroorzaken, vooral bij behandeling gedurende meer dan 7 dagen, en kan deze zeker in aanwezigheid van andere risicofactoren klinisch belangrijk zijn.

(O’Connell 2009) O’Connell K, Davis AR, Kerns J. Oral contraceptives: side effects and depression in adolescent girls.
(O’Connell 2009) O’Connell K, Davis AR, Kerns J. Oral contraceptives: side effects and depression in adolescent girls. Contraception

Commenté des Médicaments 34 , Farmacotherapeutisch Kompas 35 , British National Formulary 36 , Martindale 37 , Meyler’s Side Effects of Drugs 38 , Geriatric Dosage Handbook 39 , Managing Clinically Important Drug Interactions 40 , Drug Information AHFS 41 .
Gecommentarieerd Geneesmiddelenrepertorium 34 , Farmacotherapeutisch Kompas 35 , British National Formulary 36 , Martindale 37 , Meyler’s Side Effects of Drugs 38 , Geriatric Dosage Handbook 39 , Managing Clinically Important Drug Interactions 40 , Drug Information AHFS 41 .

D'autres sources mentionnent qu'outre le sulindac, le diclofénac présente aussi un risque important d'hépatotoxicité [Journal of Hepatology, 29, 135- 141 (1998); Meyler's Side Effects of Drugs, 14 ème éd.].
Andere bronnen vermelden naast sulindac ook voor diclofenac een belangrijk risico van hepatotoxiciteit [Journal of Hepatology 29, 135-141 (1998); Meyler’s Side Effects of Drugs, 14 de editie].

348, 529-537 (2003) W.E. Evans et H.L. McLeod: Pharmacogenomics - Drug disposition, drug targets and side effects.
348, 529-537 (2003) W.E. Evans en H.L. McLeod: Pharmacogenomics - Drug disposition, drug targets and side effects.