The glucose 6-phosphate is first oxidized to gluconate 6-phosphate by nicotinamide adenine dinucleotide phosphate (NADP) in the presence of the enzyme glucose 6-phosphate dehydrogenase (G6PDH).
Het glucose-6-fosfaat wordt met nicotinezuuramide-adenine-dinucleotide-fosfaat (NADP) in aanwezigheid van het enzym glucose-6-fosfaatdehydrogenase (G6PDH) geoxideerd tot gluconaat-6-fosfaat.